Drought-stressed cotton often has thick cuticles and leathery leaves that inhibit the uptake of many defoliants. The potential for re-growth is often high due to unused nitrogen remaining after premature cutout. The uptake of Freefall appears to be slightly inhibited in drought-stressed cotton and higher rates may be needed. Ginstar delivers a liquid form of thidiazuron and limited research suggests that their uptake may be less affected by drought-stressed cotton than wettable powder formulations of Freefall. Tank mixtures with Folex , as well as the addition of silicone surfactants or ammonium sulfate, have been shown to increase the uptake of Freefall on drought-stressed cotton. However, use caution when applying higher rates or adjuvants in warmer weather, as desiccation and stuck leaves may result.

Drought-stressed cotton has thicker cuticles that limit the penetration of some products. In high temperatures, combinations of herbicidal-type defoliants may desiccate leaves. Re-growth is often a problem if rainfall occurs following application. Re-growth can be a concern with applications of Folex alone or tank-mixed with ethephon, depending on moisture conditions and temperature following application. Activity of most defoliants is reduced under cooler conditions, and higher rates will be needed. Re-growth is generally not as big a concern as with warmer temperatures. Boll openers should be added to all treatments to ensure boll opening in the event of freezing temperatures.